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Testrol efectos secundarios
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The levels of total and free active thyroid hormone (T3) are decreased with anabolic steroid use, and T4 thyroid hormone-binding globulin levels are markedly elevated(2). However, free T3 levels are not always a reliable indicator of the clinical impact of anabolic steroid treatment (11). For example, a study of 2,081 hypogonadal men demonstrated that those treated with the more potent anabolic steroids failed to meet their recommended T4 requirement (11). Similarly, in a study of 2,077 middle-aged men, serum levels of TSH were not elevated, and T4/total T3 was not significantly elevated (11). Even when T4 is elevated, the level of free T4/T3 can change dramatically (12). It is likely that the low levels of free T3 observed with anabolic steroid use in hypogonadal men also may contribute to the decrease in total T4 levels. However, a recent study in middle-aged men showed that the most commonly used anabolic steroids also had the strongest effect on free T3 and the concentration of TSH (13). In contrast, total T4 was decreased by approximately 25-fold by the most commonly used steroids and, at the same time, free T3 levels increased only 1-fold (13). So how can a hypogonadal person take anabolic steroids? It is best understood as a matter of physiology: The TSH response is determined primarily by the size, duration, and timing of the dose given, and the use of high-dose anabolic steroids may increase TSH levels significantly. The body's natural "homeostasis" is regulated by many factors, some of which are influenced by anabolic steroid treatment. It is essential to assess hypogonadal men who are taking anabolic steroids, particularly men over the age of 35, for TSH levels and to confirm any changes that have occurred. For men over the age of 35, an initial TSH assessment before initiating and/or continuing anabolic steroid treatment should be performed, since the magnitude of TSH increase tends to be greater (14). If a response to anabolic steroids is seen in an aging hypogonadal male, testing should be repeated for free T3 levels, as this is the most direct means to identify the onset of hypogonadism. Because TSH is a marker for the onset of anabolic steroid resistance (15), it can serve as a predictor for hypogonadism that has been present for months or years (16). A recent study of 2,077 middle-aged men revealed that Similar articles: